Quantitative Assessment of Portal Hypertension by Two-Dimensional Shear Wave Elastography in Rat Models of Nonalcoholic Fatty Liver Disease: Comparison With Four Composite Scores

Frontiers in Medicine

article

Bingtian Dong¹  Yuping Chen²  Guorong Lyu¹  Yongjian Chen¹  Ran Qin⁴ 

[1]Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University

[2]Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University

[3]Department of Clinical Medicine, Quanzhou Medical College

[4]Department of Ultrasound, Chenggong Hospital, Xiamen University

关键词: nonalcoholic fatty liver disease;    portal hypertension;    diagnosis;    noninvasive method;    two-dimensional shear wave elastography;   

DOI  :  10.3389/fmed.2022.844558

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Measurement of hepatic venous pressure gradients is the gold standard for assessing portal hypertension (PH) but is invasive with potential complications. We aimed to assess the performance in liver and spleen stiffness measurement (LSM and SSM, respectively) by two-dimensional shear wave elastography (2D-SWE) and composite scores including liver stiffness-spleen diameter to platelet ratio score (LSPS), platelet (PLT) count/spleen diameter ratio (PSR), aspartate aminotransferase (AST)/alanine aminotransferase ratio (AAR), and AST-to-PLT ratio index (APRI) for diagnosing PH in nonalcoholic fatty liver disease (NAFLD) rat models. Methods Animal models with PH in NAFLD were established in 65 rats, which then underwent 2D-SWE measurements. Morphological and biological parameters were collected for calculation of four composite scores. Correlations of noninvasive methods with portal venous pressure were evaluated by Spearman correlation analysis. The area under the receiver operating characteristic curve (AUC) was used to assess the performance of noninvasive methods in predicting PH. Results LSM and SSM were significantly associated with portal venous pressure ( r = 0.636 and 0.602, respectively; all P 0.05). Conclusions LSM and SSM by 2D-SWE can be used as promising noninvasive parameters for diagnosing PH in NAFLD and have higher accuracy than composite scores. The combined models, compared to LSM and SSM, did not significantly improve the performance in diagnosing PH.

【 授权许可】

CC BY