Frontiers in Medicine | |
Association Between Extracellular Superoxide Dismutase Activity and 1-Year All-Cause Mortality in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study | |
article | |
Haiqing Li1  Wei Hong3  Zixiong Zeng1  Shan Gong1  Fan Wu2  Zihui Wang2  Heshen Tian2  Juan Cheng1  Ruiting Sun2  Mi Gao3  Chunxiao Liang2  Weitao Cao2  Guoping Hu1  Yuqun Li1  Liping Wei1  Yumin Zhou2  Pixin Ran2  | |
[1] Department of Respiratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University;State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University;GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University | |
关键词: AECOPD; extracellular superoxide dismutase (ecSOD); SOD3; mortality; prognosis; | |
DOI : 10.3389/fmed.2022.811975 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
【 摘 要 】
Background and Objectives Accumulating evidence suggests that oxidative stress is involved in the development of chronic obstructive pulmonary disease (COPD) and its progression. Activity of extracellular superoxide dismutase (ecSOD), the only extracellular enzyme eliminating superoxide radicals, has been reported to decline in acute exacerbations of COPD (AECOPD). However, the association between serum ecSOD activity and 1-year all-cause mortality in AECOPD patients remains unclear. The objective of our study was to explore the usefulness of ecSOD activity on admission in AECOPD as an objective predictor for 1-year all-cause mortality. Methods We measured serum ecSOD activity in AECOPD patients on admission in a prospective cohort study. We also recorded their laboratory and clinical data. Multivariate Cox regression was used to analyze the association between ecSOD activity and the risk of 1-year all-cause mortality. Restricted cubic spline curves were used to visualize the relationship between ecSOD activity and the hazard ratio of 1-year all-cause mortality. Results A total of 367 patients were followed up for 1 year, and 29 patients died during a 1-year follow-up period. Compared with survivors, the non-survivors were older (79.52 ± 8.39 vs. 74.38 ± 9.34 years old, p = 0.004) and had increased levels of tobacco consumption (47.07 ± 41.67 vs. 33.83 ± 31.79 pack-years, p = 0.037). Having an ecSOD activity ≤ 98.8 U/ml was an independent risk factor of 1-year all-cause mortality after adjustment for baseline differences, clinical variables and comorbidities [hazard ratio = 5.51, 95% confidence interval (CI): 2.35–12.95, p < 0.001]. Conclusion Lower serum ecSOD activity was a strong and independent predictor of 1-year all-cause mortality in AECOPD patients.
【 授权许可】
CC BY
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