Association Between Extracellular Superoxide Dismutase Activity and 1-Year All-Cause Mortality in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study

Frontiers in Medicine

article

Haiqing Li¹  Wei Hong³  Zixiong Zeng¹  Shan Gong¹  Fan Wu²  Zihui Wang²  Heshen Tian²  Juan Cheng¹  Ruiting Sun²  Mi Gao³  Chunxiao Liang²  Weitao Cao²  Guoping Hu¹  Yuqun Li¹  Liping Wei¹  Yumin Zhou²  Pixin Ran² 

[1]Department of Respiratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University

[2]State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University

[3]GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University

关键词: AECOPD;    extracellular superoxide dismutase (ecSOD);    SOD3;    mortality;    prognosis;   

DOI  :  10.3389/fmed.2022.811975

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background and Objectives Accumulating evidence suggests that oxidative stress is involved in the development of chronic obstructive pulmonary disease (COPD) and its progression. Activity of extracellular superoxide dismutase (ecSOD), the only extracellular enzyme eliminating superoxide radicals, has been reported to decline in acute exacerbations of COPD (AECOPD). However, the association between serum ecSOD activity and 1-year all-cause mortality in AECOPD patients remains unclear. The objective of our study was to explore the usefulness of ecSOD activity on admission in AECOPD as an objective predictor for 1-year all-cause mortality. Methods We measured serum ecSOD activity in AECOPD patients on admission in a prospective cohort study. We also recorded their laboratory and clinical data. Multivariate Cox regression was used to analyze the association between ecSOD activity and the risk of 1-year all-cause mortality. Restricted cubic spline curves were used to visualize the relationship between ecSOD activity and the hazard ratio of 1-year all-cause mortality. Results A total of 367 patients were followed up for 1 year, and 29 patients died during a 1-year follow-up period. Compared with survivors, the non-survivors were older (79.52 ± 8.39 vs. 74.38 ± 9.34 years old, p = 0.004) and had increased levels of tobacco consumption (47.07 ± 41.67 vs. 33.83 ± 31.79 pack-years, p = 0.037). Having an ecSOD activity ≤ 98.8 U/ml was an independent risk factor of 1-year all-cause mortality after adjustment for baseline differences, clinical variables and comorbidities [hazard ratio = 5.51, 95% confidence interval (CI): 2.35–12.95, p < 0.001]. Conclusion Lower serum ecSOD activity was a strong and independent predictor of 1-year all-cause mortality in AECOPD patients.

【 授权许可】

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