Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients

Frontiers in Medicine

article

Yiling Fang¹  Yaru Xu⁴  Silu Cao⁴  Xiaoru Sun¹  Hui Zhang⁴  Qi Jing⁴  Li Tian¹  Cheng Li¹ 

[1] Department of Anesthesiology and Perioperative Medicine, School of Medicine, Shanghai Fourth People’s Hospital, Tongji University;School of Medicine, Shanghai Fourth People’s Hospital, Translational Research Institute of Brain and Brain-Like Intelligence, Tongji University;Clinical Research Center for Anesthesiology and Perioperative Medicine, Tongji University;Department of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine;Department of General Practice, Zhangjiagang First People’s Hospital, Affiliated to Soochow University School of Medicine

关键词: deep sedation;    propofol anesthesia;    hypoxia;    patient anxiety;    painless artificial abortion;   

DOI  :  10.3389/fmed.2022.763275

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Respiratory depression is a life-threatening adverse effect of deep sedation. This study aimed to investigate the factors related to hypoxia caused by propofol during intravenous anesthesia. Methods Three hundred and eight patients who underwent painless artificial abortion in the outpatient department of Shanghai Tenth People’s Hospital between November 1, 2019 and June 30, 2020 were divided into two groups according to whether the patients experienced hypoxia (SpO 2 < 95%). Preoperative anxiety assessments, anesthesia process, and operation-related information of the two groups were analyzed. The univariate analysis results were further incorporated into logistic regression analysis for multivariate analysis to determine the independent risk factors affecting hypoxia. Results Univariate analysis revealed that body mass index (BMI) (21.80 ± 2.94 vs. 21.01 ± 2.39; P = 0.038, 95% confidence interval (CI) = [−1.54, −0.04]), propofol dose (15.83 ± 3.21 vs. 14.39 ± 3.01; P = 0.002, CI = [−2.34, −0.53]), menopausal days (49.64 ± 6.03 vs. 52.14 ± 5.73; P = 0.004, CI = [0.79, 4.21]), State Anxiety Inventory score (51.19 ± 7.55 vs. 44.49 ± 8.96; P < 0.001, CI = [−9.26, −4.15]), and Self-rating Anxiety Scale score (45.86 ± 9.48 vs. 42.45 ± 9.88; P = 0.021, CI = [−6.30, −0.53]) were statistically significant risk factors for hypoxia during the operation. Logistic regression analysis showed that propofol dosage, menopausal days, and State Anxiety Inventory score were independent risk factors for hypoxia. Conclusion Patient anxiety affects the incidence of hypoxia when undergoing deep intravenous anesthesia with propofol. We can further speculate that alleviating patient anxiety can reduce the incidence of hypoxia.

【 授权许可】

CC BY