Case Report: An Ulceration With a Stalactite Appearance on the Index Finger

Frontiers in Medicine

article

Liangliang Zhang¹  Yalan Dai²  Mengting Lin¹  Qiuyun Xu¹  Tingting Lin¹  Ting Gong³  Bo Cheng¹  Chao Ji¹  Donghua Cai² 

[1] Department of Dermatology, The First Affiliated Hospital of Fujian Medical University;Department of Dermatology, Shishi Municipal General Hospital;Central Laboratory, The First Affiliated Hospital of Fujian Medical University

关键词: Proteus mirabilis;    cutaneous exanthem;    next generation sequencing;    Proteus spp;    bacteria;    human infection;   

DOI  :  10.3389/fmed.2022.801086

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Proteus mirabilis , the most widespread species of all Proteus spp. bacteria, is proven to be one of the most universal pathogens in chronic wounds. In this case, a woman in her 40s consulted a physician about an asymptomatic ulceration with a stalactite appearance at the distal end of the index finger after she was exposed to a needle when vaccinating chickens. The patient did not response to ceftazidime. Physical examination revealed a well-demarcated violescent ulceration with a stalactite appearance at the distal end of the index finger. A biopsy of the lesion showed dense infiltration of multinucleated giant cells, histiocytes, and lymphocytes in the dermis. The result of metagenomics next-generation sequencing (NGS) showed 306 unique sequence reads of P. mirabilis , covering 33.49% of the nucleotide sequences. The pathogen was identified as P. mirabilis , which was resistant to ceftazidime. The patient was treated with ciprofloxacin hydrochloride and improved considerably. This case reported a distinctive cutaneous lesion of P. mirabilis on human infection and showed a successful use of NGS in P. mirabilis .

【 授权许可】

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