Prevalence and Main Clinical Characteristics of Fully Vaccinated Patients Admitted to Hospital for Delta Variant COVID-19

Frontiers in Medicine

article

Matteo Vassallo¹  Nicolas Clement²  Laurene Lotte³  Sabrina Manni¹  Audrey Sindt³  Pierre M. Bertrand¹  Jacques Durant⁴ 

[1] Department of Internal Medicine/Infectious Diseases, Cannes General Hospital;Intensive Care Unit, Cannes General Hospital;Multipurpose Laboratory, Bacteriology and Virology Unit, Cannes General Hospital;Department of Infectious Diseases, Nice University Hospital

关键词: COVID-19;    delta variant;    vaccination;    patients;    hospitalization;   

DOI  :  10.3389/fmed.2022.809154

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objectives The Delta variant of the novel beta coronavirus responsible for the current coronavirus pandemic (COVID-19) spread across Europe during the summer of 2021. Little is known of vaccine efficacy on this variant. Our aim was to study the prevalence and clinical characteristics of fully vaccinated subjects admitted to hospital for Delta variant COVID-19. Methods We identified patients admitted to Cannes hospital for Delta-variant-related Covid-19 infection from July to September 2021. Their main demographic parameters, inflammatory markers, and clinical characteristics were recorded. Differences between fully vaccinated subjects and unvaccinated or incompletely vaccinated individuals were analyzed. Results We included 126 patients (57% male, mean age 64 years, mean delay since symptoms onset 7.8 days). Among admitted patients, 94 (75%) were not vaccinated, 11 (8%) incompletely so and 21 (17%) were fully vaccinated. Fully vaccinated patients were older (77 vs. 61 vs. 62 years, p = 0.003), with fewer days since symptoms onset (5.9 vs. 8.0 vs. 9.3 days, p = 0.035) than unvaccinated or incompletely vaccinated patients, respectively. Severe pneumonia was less frequent among completely vaccinated subjects (67 vs. 84 vs. 100%, p = 0.038), while rates of transfer to the ICU, mechanical ventilation or death did not differ. Thirteen fully vaccinated patients underwent a thoracic CT scan, revealing involvement of lung parenchyma in four of them. Discussion Prevalence of hospitalization for Delta-variant COVID-19 in fully vaccinated subjects was low and, despite their age and comorbid conditions, these patients had a high rate of favorable outcome.

【 授权许可】

CC BY