Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine

Frontiers in Pediatrics

article

David C. Whitcomb¹ 

[1] Cell Biology and Molecular Physiology, and Human Genetics, Division of Gastroenterology, Hepatology and Nutrition ,(Chief 1999-2016), University of Pittsburgh and UPMC;Ariel Precision Medicine

关键词: chronic pancreatitis in children;    precision medicine;    genetics;    recurrent acute pancreatitis;    CFTR (cystic fibrosis transmembrane conductance regulator);    CFTR-related disorders (CFTR-RD);    alcohol;    smoking;   

DOI  :  10.3389/fped.2022.941852

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Traditional approaches to understanding the origins of chronic pancreatitis (CP) and find treatments led to abysmal failure. Thus, no drugs now exists to meet this need. Outdated concepts of the etiopathogenesis of CP have been replaced with new insights and disease models that provide the framework for early detection of the pathogenic pancreatitis process. Application of these principals require a new paradigm in disease definition and management, i.e. personalized / precision medicine. The key is acute pancreatitis (AP) starting with the first (sentinel) acute pancreatitis (AP) event (SAPE). This event sensitizes the pancreas to recurrent acute pancreatitis (RAP) as ongoing stressors drive various inflammatory responses to cause CP. The problem is the complex etiologies of AP and the additional genetic and environmental factors that promote progression to RAP and CP. This paper provides a background on the key conceptual changes that facilitate new approaches and the rationale for using mechanism-specific therapies to prevent RAP and CP.

【 授权许可】

CC BY