Cerebral Oxygenation in Preterm Infants Developing Cerebral Lesions

Frontiers in Pediatrics

article

Angelika L. Schwab¹  Benjamin Mayer²  Dirk Bassler³  Helmut D. Hummler¹  Hans W. Fuchs¹  Manuel B. Bryant¹ 

[1] Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, University Hospital Ulm;Institute of Epidemiology and Medical Biometry, Ulm University;Neonatal Department, University Hospital Zurich, University of Zurich

关键词: preterm infant;    intraventricular hemorrhage (IVH);    periventricular leukomalacia (PVL);    near-infrared spectroscopy (NIRS);    cStO 2;    cerebral oxygenation;    cerebral ischemia;   

DOI  :  10.3389/fped.2022.809248

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: We investigated the association between cerebral tissue oxygen saturation (cStO2) measured by near-infrared spectroscopy (NIRS) and cerebral lesions including intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). Methods: Preterm infants 5 min was regarded a critical event. The study was registered on clinicaltrials.gov (ID NCT01430728, URL: https://clinicaltrials.gov/ct2/ show/NCT01430728?id=NCT01430728&draw=2&rank=1). Results: Of 162 infants (gestational age: mean 27.2 weeks, standard deviation 20 days; birth weight: mean 852 g, standard deviation 312 g) recorded, 24/12 (14.8%/7.4) developed any/severe IVH/PVL. Mean cStO2 was significantly lower in infants with IVH/PVL as well as severe IVH/PVL. In addition, we observed critical events defined by mean cStO2 over 5 min <60% in four infants with severe IVH/PVL during NIRS monitoring. AUT showed no statistically significant difference between outcome groups. Conclusion: These findings suggest that cStO2 is lower in infants developing IVH/PVL. This may be related to lower oxygenation and/or perfusion and implies that cStO2 could potentially serve as an indicator of imminent cerebral lesions.

【 授权许可】

CC BY