Neurodevelopmental Outcomes of Children with Periventricular Leukomalacia

Pediatrics and Neonatology

卷:54

Takashi Imamura¹  Masahiro Watanabe¹  Mariko Kaneko¹  Katsutoshi Nagasawa¹  Yutaka Fukuda¹  Hiromichi Ariga¹  Tomoo Fujiki¹  Yasuko Shibukawa¹  Aya Goto² 

[1] Department of Pediatrics, Takeda General Hospital, Aidu Wakamatsu City, Fukushima, Japan;

[2] Department of Public Health, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan;

关键词: cerebral palsy (CP);    magnetic resonance imaging (MRI);    motor impairment;    periventricular leukomalacia (PVL);    walking ability;   

DOI  :  10.1016/j.pedneo.2013.04.006

来源: DOAJ

【 摘 要 】

To examine the neurodevelopmental outcomes of children with periventricular leukomalacia (PVL).Materials and methods: Twenty-five children diagnosed with grade 1, 2 or 3 PVL on the basis of magnetic resonance imaging (MRI) findings between January 2002 and December 2011 were enrolled and followed from 15 months to 10 years of age.Results: Of the 25 children, one was a term and 24 were preterm-births. Nine (36%) had spastic diplegia and 12 (48%) had quadriplegia. Ten of the 25 (40%) were able to walk independently at 36 months utilizing short leg braces, whereas 13 children (52%) were unable to walk independently. MRI findings revealed grade 1 PVL in nine (36%), grade 2 in 12 (48%), and grade 3 in four (16%) of the 25 children. Eleven of the 16 children (69%) with grade 2 or 3 PVL had Papile III or IV intraventricular hemorrhage (IVH), and many of these children had severe neurologic motor abnormalities, severe psychomotor delay, and seizures. Five of the nine children (56%) with grade 1 PVL had normal psychomotor development. There were statistically significant differences in the motor impairment and walking ability between the children with grade 1 and those with grade 2 PVL (p = 0.008 and 0.005, respectively).Conclusion: Most children with grade 2 or 3 PVL had severe neurodevelopmental delays, but attention should also be paid to the 56% of children with grade 1 PVL who presented with normal psychomotor development. Further studies of larger populations, including long-term follow-up, are necessary to evaluate the outcomes of children with PVL.

【 授权许可】

Unknown