Associations Between Maternal Distress During Early Life Periods and Offspring Respiratory Infections and Allergic Outcomes

Frontiers in Pediatrics

article

Johan Gunnar Eriksson¹  Keith M. Godfrey⁶  Peter D. Gluckman¹  Yap Seng Chong¹  Jerry Kok Yen Chan⁸  Hugo Van Bever^1,10  Bee Wah Lee^1,10  Lynette Pei-chi Shek^1,10  Michael J. Meaney¹  Evelyn Xiu Ling Loo¹  Hui Xing Lau¹  Michelle Zhi Ling Kee¹  Qai Ven Yap^1,14  Elizabeth Huiwen Tham¹  Yiong Huak Chan^1,14  Anne Eng Neo Goh^1,16  Oon Hoe Teoh^1,16 

[1] Singapore Institute for Clinical Sciences ,(SICS), Agency for Science, Technology and Research;Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore;Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System;Folkhälsan Research Center;Department of General Practice and Primary Health Care, University of Helsinki;MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust;Liggins Institute, University of Auckland;Department of Reproductive Medicine, KK Women's and Children's Hospital;Academic Program in Obstetrics and Gynaecology, Duke-NUS Medical School;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore;Department of Psychiatry, Douglas Mental Health University Institute, McGill University;Sackler Program for Epigenetics and Psychobiology, McGill University;Ludmer Centre for Neuroinformatics and Mental Health, McGill University;Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore;Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System;Department of Paediatrics, KK Women's and Children's Hospital

关键词: maternal distress;    wheeze;    rhinitis;    eczema;    allergic sensitization;    preconception;    pregnancy;    postnatal;   

DOI  :  10.3389/fped.2022.749323

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Increasing evidence suggests that maternal distress is a risk factor for development of respiratory infections and allergic diseases in the offspring. We aim to evaluate the link between maternal distress during critical periods in early life, namely the preconception, pregnancy and postnatal periods, and development of respiratory infections and allergic diseases in the offspring from the Singapore PREconception Study of long Term maternal and child Outcomes (S-PRESTO) cohort. Methods Maternal perceived distress was evaluated using validated questionnaires including Beck Depression Inventory-II (BDI-II) administered during three time periods: preconception (three months apart at four timepoints), pregnancy (during each trimester) and postnatal (3 and 6 months post-delivery). Child eczema, rhinitis and wheeze outcomes were evaluated using a modified ISAAC questionnaire at ages 3, 6, 12, and 18 months. Child allergic sensitization was determined by skin prick testing at 18 months. Results Among 332 mother-child pairs studied, higher maternal distress during preconception and pregnancy increased the risks of wheeze development in the first 18 months; for example, preconception and pregnancy BDI-II scores ≥20 were associated with increased risks of wheeze by 18 months [adjusted risk ratios 3.2 (95%CI 1.1–9.4) and 2.5 (1.0–5.9), respectively]. Emotional and practical support from family during preconception decreased the risks of offspring wheeze. No associations were observed between maternal distress and offspring eczema, rhinitis and allergic sensitization. Conclusion Maternal distress during critical early life periods was associated with offspring wheeze in the first 18 months of life. Supporting maternal mental health even before pregnancy could reduce the risk of offspring wheeze.

【 授权许可】

CC BY