The Burden of Critical Illness in Hospitalized Children in Low- and Middle-Income Countries: Protocol for a Systematic Review and Meta-Analysis

Frontiers in Pediatrics

article

Teresa B. Kortz¹  Katie R. Nielsen³  Rishi P. Mediratta⁵  Hailey Reeves²  Nicole F. O'Brien⁶  Jan Hau Lee⁷  Jonah E. Attebery⁹  Emaan G. Bhutta^1,10  Carter Biewen¹  Alvaro Coronado Munoz^1,11  Mary L. deAlmeida^1,12  Yudy Fonseca^1,13  Shubhada Hooli^1,14  Hunter Johnson⁶  Niranjan Kissoon^1,15  Mara L. Leimanis-Laurens^1,17  Amanda M. McCarthy^1,11  Carol Pineda^1,19  Kenneth E. Remy^2,20  Sara C. Sanders⁶  Yemisi Takwoingi^2,22  Matthew O. Wiens^2,24  Adnan T. Bhutta^1,13 

[1] Division of Critical Care, Department of Pediatrics, University of California;Institute for Global Health Sciences, University of California;Division of Critical Care, Department of Pediatrics, University of Washington;Department of Global Health, University of Washington;Division of Pediatric Hospital Medicine, Department of Pediatrics, Stanford University School of Medicine;Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University/Nationwide Children's Hospital;Children's Intensive Care Unit, KK Women's and Children's Hospital;SingHealth Duke-NUS Global Health Institute;Division of Critical Care, Department of Pediatrics, University of Colorado;Eberly College of Science, Pennsylvania State University, State College;Division of Critical Care, Department of Pediatrics, University of Texas Health Science Center at Houston;Division of Critical Care, Department of Pediatrics, Emory University;Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland School of Medicine;Section of Pediatric Emergency Medicine, Department of Pediatrics, Baylor College of Medicine;Children's and Women's Global Health, University of British Columbia;Department of Pediatrics and Emergency Medicine, University of British Columbia;Pediatric Critical Care Unit, Helen DeVos Children's Hospital;Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University;Division of Critical Care, Department of Pediatrics, Baystate Medical Center, University of Massachusetts Chan Medical School;Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine;Division of Pediatric Critical Care Medicine, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University;Test Evaluation Research Group, Institute of Applied Health Research, University of Birmingham;National Institute for Health Research Birmingham Biomedical Research Centre, University Hospitals Birmingham National Health Service Foundation Trust and University of Birmingham;Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia;Mbarara University of Science and Technology

关键词: critical illness;    resource limited setting;    pediatrics—children;    child health;    global health;    hospitalization;    low;    and middle-income countries (LMIC);   

DOI  :  10.3389/fped.2022.756643

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background The majority of childhood deaths occur in low- and middle-income countries (LMICs). Many of these deaths are avoidable with basic critical care interventions. Quantifying the burden of pediatric critical illness in LMICs is essential for targeting interventions to reduce childhood mortality. Objective To determine the burden of hospitalization and mortality associated with acute pediatric critical illness in LMICs through a systematic review and meta-analysis of the literature. Data Sources and Search Strategy We will identify eligible studies by searching MEDLINE, EMBASE, CINAHL, and LILACS using MeSH terms and keywords. Results will be limited to infants or children (ages >28 days to 12 years) hospitalized in LMICs and publications in English, Spanish, or French. Publications with non-original data (e.g., comments, editorials, letters, notes, conference materials) will be excluded. Study Selection We will include observational studies published since January 1, 2005, that meet all eligibility criteria and for which a full text can be located. Data Extraction Data extraction will include information related to study characteristics, hospital characteristics, underlying population characteristics, patient population characteristics, and outcomes. Data Synthesis We will extract and report data on study, hospital, and patient characteristics; outcomes; and risk of bias. We will report the causes of admission and mortality by region, country income level, and age. We will report or calculate the case fatality rate (CFR) for each diagnosis when data allow. Conclusions By understanding the burden of pediatric critical illness in LMICs, we can advocate for resources and inform resource allocation and investment decisions to improve the management and outcomes of children with acute pediatric critical illness in LMICs.

【 授权许可】

CC BY