The Burden of Critical Illness in Hospitalized Children in Low- and Middle-Income Countries: Protocol for a Systematic Review and Meta-Analysis

Frontiers in Pediatrics

卷:10

Emaan G. Bhutta²  Amanda M. McCarthy³  Alvaro Coronado Munoz³  Kenneth E. Remy⁴  Mary L. deAlmeida⁵  Adnan T. Bhutta⁷  Yudy Fonseca⁷  Yemisi Takwoingi⁸  Shubhada Hooli¹⁰  Matthew O. Wiens¹²  Niranjan Kissoon¹³  Mara L. Leimanis-Laurens¹⁵  Carol Pineda¹⁶  Katie R. Nielsen¹⁸  Sara C. Sanders¹⁹  Hunter Johnson¹⁹  Nicole F. O'Brien¹⁹  Carter Biewen²⁰  Jonah E. Attebery²¹  Rishi P. Mediratta²³  Teresa B. Kortz²⁴  Hailey Reeves²⁴  Jan Hau Lee²⁵ 

[1] 0Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States;

[2] 0Eberly College of Science, Pennsylvania State University, State College, PA, United States;

[3] 1Division of Critical Care, Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX, United States;

[4] 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, United States;

[5] 2Division of Critical Care, Department of Pediatrics, Emory University, Atlanta, GA, United States;

[6] 2Test Evaluation Research Group, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom;

[7] 3Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States;

[8] 3National Institute for Health Research Birmingham Biomedical Research Centre, University Hospitals Birmingham National Health Service Foundation Trust and University of Birmingham, Birmingham, United Kingdom;

[9] 4Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada;

[10] 4Section of Pediatric Emergency Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States;

[11] 5Children's and Women's Global Health, University of British Columbia, Vancouver, BC, Canada;

[12] 5Mbarara University of Science and Technology, Mbarara, Uganda;

[13] 6Department of Pediatrics and Emergency Medicine, University of British Columbia, Vancouver, BC, Canada;

[14] 7Pediatric Critical Care Unit, Helen DeVos Children's Hospital, Grand Rapids, MI, United States;

[15] 8Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, United States;

[16] 9Division of Critical Care, Department of Pediatrics, Baystate Medical Center, University of Massachusetts Chan Medical School, Springfield, MA, United States;

[17] Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore, Singapore;

[18] Department of Global Health, University of Washington, Seattle, WA, United States;

[19] Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University/Nationwide Children's Hospital, Columbus, OH, United States;

[20] Division of Critical Care, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States;

[21] Division of Critical Care, Department of Pediatrics, University of Colorado, Aurora, CO, United States;

[22] Division of Critical Care, Department of Pediatrics, University of Washington, Seattle, WA, United States;

[23] Division of Pediatric Hospital Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States;

[24] Institute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, United States;

[25] SingHealth Duke-NUS Global Health Institute, Singapore, Singapore;

关键词: critical illness;    resource limited setting;    pediatrics—children;    child health;    global health;    hospitalization;   

DOI  :  10.3389/fped.2022.756643

来源: DOAJ

【 摘 要 】

BackgroundThe majority of childhood deaths occur in low- and middle-income countries (LMICs). Many of these deaths are avoidable with basic critical care interventions. Quantifying the burden of pediatric critical illness in LMICs is essential for targeting interventions to reduce childhood mortality.ObjectiveTo determine the burden of hospitalization and mortality associated with acute pediatric critical illness in LMICs through a systematic review and meta-analysis of the literature.Data Sources and Search StrategyWe will identify eligible studies by searching MEDLINE, EMBASE, CINAHL, and LILACS using MeSH terms and keywords. Results will be limited to infants or children (ages >28 days to 12 years) hospitalized in LMICs and publications in English, Spanish, or French. Publications with non-original data (e.g., comments, editorials, letters, notes, conference materials) will be excluded.Study SelectionWe will include observational studies published since January 1, 2005, that meet all eligibility criteria and for which a full text can be located.Data ExtractionData extraction will include information related to study characteristics, hospital characteristics, underlying population characteristics, patient population characteristics, and outcomes.Data SynthesisWe will extract and report data on study, hospital, and patient characteristics; outcomes; and risk of bias. We will report the causes of admission and mortality by region, country income level, and age. We will report or calculate the case fatality rate (CFR) for each diagnosis when data allow.ConclusionsBy understanding the burden of pediatric critical illness in LMICs, we can advocate for resources and inform resource allocation and investment decisions to improve the management and outcomes of children with acute pediatric critical illness in LMICs.

【 授权许可】

Unknown