Eastern India Collaboration on Multisystem Inflammatory Syndrome in Children (EICOMISC): A Multicenter Observational Study of 134 Cases

Frontiers in Pediatrics

article

Snehamayee Nayak¹  Prakash Chandra Panda²  Basudev Biswal³  Sunil Kumar Agarwalla⁴  Amit Kumar Satapathy⁵  Pradeep Kumar Jena¹  Krishna Mohan Gulla⁵  Debasmita Rath³  Anuspandana Mahapatra³  Pravakar Mishra¹  Debashree Priyadarshini³  Samarendra Mahapatro⁵  Saurav Nayak⁵  Rashmi Ranjan Das⁵ 

[1] SCB Medical College, Sardar Vallabhbhai Patel Post Graduate Institute of Paediatrics;Department of Pediatrics, Veer Surendra Sai Institute of Medical Sciences and Research;Department of Pediatrics, Institute of Medical Sciences ,(IMS) and SUM Hospital;Department of Pediatrics, Maharaja Krushna Chandra Gajapati ,(MKCG) Medical College and Hospital;Department of Pediatrics and Biochemistry, All India Institute of Medical Sciences ,(AIIMS)

关键词: SARS-CoV-2;    MIS-C;    PIMS-TS;    COVID-19;    coronary arterial lesions;    Kawasaki disease (syndrome);    developing country;    low and middle income country (LMIC);   

DOI  :  10.3389/fped.2022.834039

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Few single center studies from resource-poor settings have reported about the epidemiology, clinical feature and outcome of multisystem inflammatory syndrome in children (MIS-C). However, larger data from multi-center studies on the same is lacking including from Indian setting. Methods This retrospective collaborative study constituted of data collected on MIS-C from five tertiary care teaching hospitals from Eastern India. Children ≤ 15 years of age with MIS-C as per the WHO criteria were included. Primary outcome was mortality. Results A total of 134 MIS-C cases were included (median age, 84 months; males constituted 66.7%). Fever was a universal finding. Rash was present in 40%, and conjunctivitis in 71% cases. Gastro-intestinal and respiratory symptoms were observed in 50.7% and 39.6% cases, respectively. Co-morbidity was present in 23.9% cases. Shock at admission was noted in 35%, and 27.38% required mechanical ventilation. Fifteen (11.2%) children died. The coronary abnormalities got normalized during follow-up in all except in one child. Initial choice of immunomodulation had no effect on the outcomes. Presence of underlying co-morbidity, lymphopenia, thrombocytosis, hyponatremia, increased LDH (>300 U/L), and hypoalbuminemia were the factors significantly associated an increased mortality. Conclusions MIS-C has myriad of manifestations. Underlying co-morbidity, lymphopenia, thrombocytosis, hyponatremia, increased LDH (>300 U/L), and hypoalbuminemia were associated with an increased mortality. No difference in outcome was noted with either steroid or IVIg or both. Coronary artery abnormalities resolved in nearly all cases.

【 授权许可】

CC BY