Hepatitis B Infection Among Pregnant Women in China: A Systematic Review and Meta-Analysis

Frontiers in Public Health

article

Dan Liu¹  Yan Liu¹  Jiaqi Ni¹  Hailong Li¹  Linan Zeng¹  Chuan Zhang¹  Li Zhang²  Qin Yu²  Bin Wu⁶  Lingli Zhang¹ 

[1] Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education;West China School of Pharmacy, Sichuan University;Departments of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University;National Drug Clinical Trial Institute, West China Second University Hospital, Sichuan University;Medical Decision and Economic Group, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

关键词: hepatitis B;    infectious disease transmission;    pregnant women;    prevalence;    China;    systematic review;    meta-analysis;   

DOI  :  10.3389/fpubh.2022.879289

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background A study of the current situation and characteristics of hepatitis B virus (HBV) infection among Chinese pregnant women is meaningful to provide baseline information for future research and policy making, with an aim to eliminate HBV in China. Objectives To provide the epidemiological status of HBV infection among pregnant women in China. Methods PubMed, EMbase, The Cochrane Library, and three Chinese databases were searched. Cohort studies and cross-sectional studies on HBV prevalence in Chinese pregnant women, published after 2016, were retrieved. In addition, combined HBV prevalence and 95% confidence interval (CI) were calculated. This research was registered in PROSPERO (CRD42021289123). Main Results A total of 42 studies were included in the study, with a sample size of 4,007,518 cases, and 20 provinces in China. The prevalence of HBV in Chinese pregnant women was 6.64% (95% CI: 5.72–7.57%) during the period between 2016 and 2021. Among HBsAg positive pregnant women, the HBeAg positive rate was 25.80% (95% CI: 22.26–29.69%). Moreover, geographic regions with HBV prevalence ranking from high to low were in western China, eastern China, and central China, successively. Conclusion The prevalence of HBV in Chinese pregnant women is intermediate endemic, although disparities exist between different regions. Among pregnant women with HBV infection, a high proportion of the patients have strong infectivity. Factors affecting HBV prevalence remain controversial, which demands further studies.

【 授权许可】

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