A Multicenter Cohort Study on the Adverse Effects Evaluation After Messenger RNA COVID-19 Vaccination Among Pregnant Healthcare Employees in Penang General Hospitals

Frontiers in Public Health

article

Ann Lisa Arulappen¹  Monica Danial²  Gaiyathri Shanmugam¹  Joo Thye Cheng³  Mairin Dulasi⁴  Ting Soo Chow⁵ 

[1] Department of Pharmacy, Seberang Jaya Hospital, Ministry of Health;Clinical Research Center, Seberang Jaya Hospital, Ministry of Health;Department of Medicine, Seberang Jaya Hospital, Ministry of Health;Department of Obstetrics & Gynecology, Seberang Jaya Hospital, Ministry of Health;Department of Medicine, Penang Hospital, Ministry of Health

关键词: COVID-19 vaccine;    mRNA vaccine;    pregnancy outcome;    adverse effects post vaccination;    neonatal outcomes;    safety of mRNA vaccine;   

DOI  :  10.3389/fpubh.2022.876966

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction The year 2020 saw the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which became a great threat to public health worldwide. The exponential spread of the disease with millions of lives lost worldwide saw the emergence of an accelerated vaccine development with emergency approval from well-known regulatory bodies such as the US Food and Drug Administration, followed by widespread vaccine deployment despite a paucity in safety profile data. This issue becomes even more pronounced when it involves expectant mothers considering the possible undesirable effect toward the unborn child. Method This was a retrospective cohort study which was conducted at six general hospitals in the state of Penang, Malaysia. All the pregnant employees who have consented to take the mRNA COVID-19 vaccine and participate in this study were monitored from the time of their first vaccination and up to 28 days after they delivered their babies. Results All the participants had adequate maximum vertical pocket (MVP) and no obvious anomalies or detection of intrauterine growth restriction (IUGR) were detected during the second trimester. However, one subject was reported to have miscarried during the second trimester. The reported mean neonate birth weight was 3.0 kg with the mean Apgar score of 8.8 and 9.8 at 1 and 5 min, respectively. Approximately seven (5.8%) neonates were reported to be small for their gestational age. Another three (2.5%) neonates were reported to have anomalies. Conclusion As a whole, the inference that can be made from this study is that mRNA COVID-19 vaccine appears to be safe in pregnant women regardless of the trimester as the findings did not show obvious safety warning signs.

【 授权许可】

CC BY