Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review

Microorganisms

Shashank Bhargava¹  Sara Yumeen²  George Kroumpouzos²  Maria Eleni Paroikaki³  Eleftherios Mylonakis⁴ 

[1] Department of Dermatology, R.D. Gardi Medical College, Ujjain 456010, India;Department of Dermatology, Warren Alpert Medical School at Brown University, Providence, RI 02903, USA;Department of School of Medicine, Imperial College London, London SW7 2BX, UK;Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA;

关键词: COVID-19 vaccine;    mRNA vaccine;    rash;    skin reaction;    delayed hypersensitivity reaction;    herpes zoster;   

DOI  :  10.3390/microorganisms10030624

来源: DOAJ

【 摘 要 】

Because of the increasing emergence of cutaneous reactions from COVID-19 vaccines worldwide, we investigated the published reports of these complications. We searched the PubMed, Google Scholar, and Scopus databases and the preprint server bioRxiv for articles on cutaneous complications linked to mRNA-1273 (Moderna), BNT162b2 (Pfizer–BioNTech), and AZD1222 (AstraZeneca–Oxford University) vaccines published until 30 September 2021. Eighty studies describing a total of 1415 reactions were included. Cutaneous reactions were more prevalent in females (81.6%). Delayed large local reactions were the most common complication (40.4%), followed by local injection site reactions (16.5%), zoster (9.5%), and urticarial eruptions (9.0%). Injection site and delayed large local reactions were predominantly caused by the mRNA-1273 vaccine (79.5% and 72.0%, respectively). BNT162b2 vaccination was more closely linked to distant reactions (50.1%) than mRNA-1273 (30.0%). Zoster was the most common distant reaction. Of reactions with adequate information for both vaccine doses, 58.3% occurred after the first dose only, 26.9% after the second dose only, and 14.8% after both doses. Overall, a large spectrum of cutaneous reaction patterns occurred following the COVID-19 vaccination. Most were mild and without long-term health implications. Therefore, the occurrence of such dermatologic complications does not contraindicate subsequent vaccination.

【 授权许可】

Unknown