Long-Term Exposure to Fine Particulate Matter and the Deterioration of Estimated Glomerular Filtration Rate: A Cohort Study in Patients With Pre-End-Stage Renal Disease

Frontiers in Public Health

article

Yu-Hsien Wu¹  Chih-Da Wu²  Mu-Chi Chung⁴  Cheng-Hsu Chen⁴  Laing-You Wu⁷  Chi-Jung Chung⁷  Hui-Tsung Hsu⁷ 

[1] School of Medicine, China Medical University;Department of Geomatics, National Cheng Kung University;Adjunct Associate Research Fellow, National Institute of Environmental Health Sciences, National Health Research Institutes;Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital;Ph.D. Program in Translational Medicine, National Chung Hsing University;Rong Hsing Research Center for Translational Medicine, National Chung Hsing University;Department of Public Health, China Medical University;Department of Medical Research, China Medical University Hospital

关键词: PM 2.5;    NO 2;    land-use regression model;    eGFR;    pre-ESRD;   

DOI  :  10.3389/fpubh.2022.858655

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Limited literature has explored the effect of air pollutants on chronic kidney disease (CKD) progression, especially for patients with pre-end-stage renal disease (pre-ESRD). In this study, we reported the linear and nonlinear relationships of air pollutants of particles with diameter 5 ml/min/1.73 m 2 /year. Hybrid kriging/land-use regression models were used to estimate the individual exposure levels of PM 2.5 and NO 2 . The relationships of air pollutants with eGFR deterioration were evaluated using Cox proportional hazard models. After adjusting for smoking status, baseline eGFR stages, and other traditional clinical factors, the risk of eGFR deterioration was found to increase with increasing PM 2.5 and NO 2 level ( p < 0.0001 and p = 0.041, respectively), especially for those exposed to PM 2.5 ≥ 31.44 μg/m 3 or NO 2 ≥ 15.00 ppb. Similar results were also found in the two-pollutant models. Nonlinear dose–response relationships of eGFR deterioration were observed for concentrations of 26.11 μg/m 3 for PM 2.5 and 15.06 ppb for NO 2 . In conclusion, linear and nonlinear associations between PM 2.5 and NO 2 levels and the incidence risk of eGFR deterioration were observed in patients with pre-ESRD.

【 授权许可】

CC BY