Inflammatory Indexes for Assessing the Severity and Disease Progression of Ulcerative Colitis: A Single-Center Retrospective Study

Frontiers in Public Health

article

Hanyang Lin¹  Zhaohui Bai¹  Qiong Wu⁴  Guiyang Chu⁵  Yongguo Zhang¹  Xiaozhong Guo¹  Xingshun Qi¹ 

[1] Department of Gastroenterology, General Hospital of Northern Theater Command;Postgraduate College, China Medical University;Postgraduate College, Shenyang Pharmaceutical University;Department of Thoracic Surgery, General Hospital of Northern Theater Command;Information Section of Medical Security Center, General Hospital of Northern Theater Command

关键词: ulcerative colitis;    inflammatory indexes;    activity;    severity;    5-aminosalicylic acid;   

DOI  :  10.3389/fpubh.2022.851295

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Active and severe ulcerative colitis (UC) and non-response to 5-aminosalicylic acid (5-ASA) are related to poor outcomes and should be accurately identified. Several integrated inflammatory indexes are potentially useful to assess the disease severity in patients with acute or critical diseases but are underexplored in patients with UC. Methods Patients with UC consecutively admitted to our hospital between January 2015 and December 2020 were retrospectively grouped according to the activity and severity of UC and response to 5-ASA. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), neutrophil-to-platelet ratio (NPR), platelet-to-albumin ratio (PAR), C-reactive protein-to-albumin ratio (CAR), and C-reactive protein-to-lymphocyte ratio (CLR) were calculated. The areas under receiver operating characteristic curves (AUC) were calculated. Results Overall, 187 patients with UC were included, of whom 151 were active, 55 were severe, and 14 were unresponsive to 5-ASA. The active UC group had significantly higher NLR, PLR, SII, and PAR levels. SII had the greatest predictive accuracy for active UC, followed by PLR, PAR, and NLR (AUC = 0.647, 0.641, 0.634, and 0.626). The severe UC group had significantly higher NLR, PLR, SII, PAR, CAR, and CLR levels. CLR had the greatest predictive accuracy for severe UC, followed by CAR, PLR, SII, NLR, and PAR (AUC = 0.732, 0.714, 0.693, 0.669, 0.646, and 0.63). The non-response to the 5-ASA group had significantly higher CAR and CLR levels. CAR had a greater predictive accuracy for non-response to 5-ASA than CLR (AUC = 0.781 and 0.759). Conclusion SII, CLR, and CAR may be useful for assessing the severity and progression of UC, but remain not optimal.

【 授权许可】

CC BY