Clinical Significance of Serum Oxidative Stress Markers to Assess Disease Activity and Severity in Patients With Non-Segmental Vitiligo

Frontiers in Cell and Developmental Biology

卷:9

Wei Dai¹  Sijia Wang¹  Kang Zeng¹  Chunying Li²  Pan Kang²  Shuli Li²  Zhubiao Ye²  Peng Han³ 

[1] Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangdong, China;

[2] Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China;

[3] Department of Otolaryngology, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China;

关键词: non-segmental vitiligo;    oxidative stress markers;    activity;    severity;    CXCL10;    vitiligo subtypes;   

DOI  :  10.3389/fcell.2021.739413

来源: DOAJ

【 摘 要 】

Non-segmental vitiligo (NSV) is a chronic autoimmune disease characterized by progressive depigmentation of the skin. Oxidative stress (OS) has been proposed as one among the main principal causes in the development and establishment of a sustained autoimmune state in patients with NSV. However, the disease-associated OS biomarkers in clinical practice are not well studied. In this study, we found significantly reduced antioxidant enzymes [catalase (CAT) and superoxide dismutase (SOD)], total antioxidant capacity (TAC), and increased levels of lipid oxidation product malondialdehyde (MDA) and oxidative DNA damage byproduct [8-hydroxy-2-deoxyguanosine (8-OHdG)] in serum of NSV patients compared with healthy controls (HC). Serum TAC, MDA, and 8-OHdG levels were correlated with disease activity in all patients with NSV and much lower in patients receiving conventional treatment in the past 1 year compared to that without treatment. In addition, both serum MDA and 8-OHdG levels were significantly correlated with CXCL10 expression in patients with NSV. And the serum TAC, MDA, and 8-OHdG levels were also correlated with affected body surface area and Vitiligo Area Scoring Index score in patients with NSV. This study demonstrates dysregulated OS status in patients with NSV and provides the evidence that the serum TAC, MDA, and 8-OHdG have a capacity to indicate the activity and severity in patients with NSV.

【 授权许可】

Unknown