Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study

Frontiers in Public Health

article

Li-Li Li¹  Yan-Hong Huang²  Jing Li³  Shu Liu⁴  Yan-Ling Chen⁵  Cheng-Zhi Jiang⁶  Zong-Jiao Chen⁴  Yan-Yan Zhuang⁷ 

[1] Department of Children's Health Prevention, Shenyang Maternity and Child Health Hospital;Department of Ophthalmology, Shenyang Women's and Children's Hospital;Department of Science and Education, Shenyang Maternity and Child Health Hospital;Department of Atmospheric Environment Monitoring, Liaoning Eco-Environmental Monitoring Center;Office of Institution, Liaoning Women and Children's Health Hospital;School of Environmental and Chemical Engineering, Shenyang Ligong University;Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University

关键词: air pollution;    case-control study;    omphalocele;    risk;    sulfur dioxide;   

DOI  :  10.3389/fpubh.2022.821905

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Evidence of the association between maternal sulfur dioxide (SO 2 ) exposure and the risk of omphalocele is limited and equivocal. We aimed to assess the aforementioned topic during the first trimester of pregnancy. A population-based case-control study was carried out in infants consisting of 292 cases of omphalocele and 7,950 healthy infant controls. Exposure to SO 2 , particulate matter with aerodynamic diameters ≤ 10 μm, and nitrogen dioxide was assessed by averaging the concentration from all stations in the mother's residential city. SO 2 exposure was categorized into three groups, with the lowest tertile defined as the reference category. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression models. Higher SO 2 exposure during the first trimester was significantly associated with omphalocele risk [per standard deviation (42 ug/m 3 ) increment: OR = 1.39, 95% CI = 1.22–1.65]. When focusing on shorter exposure windows, similar positive associations were observed for SO 2 exposure in the first and third months of pregnancy. In addition, compared with the lowest tertile, high SO 2 exposure in the second month of pregnancy increased the risk of omphalocele (OR = 2.80, 95% CI = 1.61–4.97). Maternal exposure to SO 2 during the first trimester may increase the risk of omphalocele in offspring.

【 授权许可】

CC BY