Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study

Frontiers in Public Health

Zong-Jiao Chen¹  Shu Liu¹  Li-Li Li²  Yan-Yan Zhuang³  Yan-Hong Huang⁴  Jing Li⁵  Yan-Ling Chen⁶  Cheng-Zhi Jiang⁷ 

[1] Department of Atmospheric Environment Monitoring, Liaoning Eco-Environmental Monitoring Center, Shenyang, China;Department of Children's Health Prevention, Shenyang Maternity and Child Health Hospital, Shenyang, China;Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China;Department of Ophthalmology, Shenyang Women's and Children's Hospital, Shenyang, China;Department of Science and Education, Shenyang Maternity and Child Health Hospital, Shenyang, China;Office of Institution, Liaoning Women and Children's Health Hospital, Shenyang, China;School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang, China;

关键词: air pollution;    case-control study;    omphalocele;    risk;    sulfur dioxide;   

DOI  :  10.3389/fpubh.2022.821905

来源: DOAJ

【 摘 要 】

Evidence of the association between maternal sulfur dioxide (SO2) exposure and the risk of omphalocele is limited and equivocal. We aimed to assess the aforementioned topic during the first trimester of pregnancy. A population-based case-control study was carried out in infants consisting of 292 cases of omphalocele and 7,950 healthy infant controls. Exposure to SO2, particulate matter with aerodynamic diameters ≤ 10 μm, and nitrogen dioxide was assessed by averaging the concentration from all stations in the mother's residential city. SO2 exposure was categorized into three groups, with the lowest tertile defined as the reference category. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression models. Higher SO2 exposure during the first trimester was significantly associated with omphalocele risk [per standard deviation (42 ug/m3) increment: OR = 1.39, 95% CI = 1.22–1.65]. When focusing on shorter exposure windows, similar positive associations were observed for SO2 exposure in the first and third months of pregnancy. In addition, compared with the lowest tertile, high SO2 exposure in the second month of pregnancy increased the risk of omphalocele (OR = 2.80, 95% CI = 1.61–4.97). Maternal exposure to SO2 during the first trimester may increase the risk of omphalocele in offspring.

【 授权许可】

Unknown