Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children

Frontiers in Public Health

article

Sixian Lao¹  Tao Zhou³  Ho-Chang Kuo⁴  Guoping Zhong¹  Weiwei Zeng⁶ 

[1] Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University;Guangdong Provincial Key Laboratory of New Drug Design and Evaluation;Shenzhen Baoan Women's and Children's Hospital, Jinan University;Kawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital;College of Medicine, Chang Gung University;The Second People's Hospital of Longgang District

关键词: Kawasaki disease;    coronary artery lesions;    risk factors;    antibiotics;    children;   

DOI  :  10.3389/fpubh.2022.817613

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objectives To study the impact of antibiotics used in Kawasaki disease (KD) with coronary artery lesions (CAL) and identify independent risk factors. Methodology This study reviewed the records of 287 KD patients between the years 2016 and 2020. Patients were grouped by their outcome, the CAL group, and a no-coronary artery lesions (NCAL) group, and stratified by the use of antibiotics. We collected clinical and laboratory data before the intravenous immunoglobulin (IVIG) treatment. Results The two groups of KD patients with and without CAL were compared. The results showed that there are significant differences between groups which were erythrocyte count (p = 0.045) and hemoglobin (p = 0.005), red blood cell-specific volume (p = 0.001), immature granular cells percentage (p = 0.006), total protein (p = 0.045), albumin (p = 0.041), alkaline phosphatase (p = 0.023), and chlorine (p = 0.006). After multivariate logistic regression, neutrophil granulocyte percentage (odds ratio [OR] = 1.200, 95% confidence interval [CI]: 1.008-1.428, p = 0.040), lymphocyte percentage (p = 0.028, OR = 1.243, 95% CI: 1.024-1.508, p = 0.028) and total protein (OR = 4.414, 95% CI: 1.092-17.846, p = 0.037) were found to be independent risk factors for CAL. After analyzing the cases with a history of antibiotic use, multivariate analysis showed no indicators were considered independent risk factors for CAL. Conclusion Neutrophil granulocyte percentage, Lymphocyte percentage and total protein were independent risks for CAL in KD without antibiotics use history. The use of antibiotics affected physiological indicators of KD patients.

【 授权许可】

CC BY