Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children

Frontiers in Public Health

卷:10

Ho-Chang Kuo¹  Guoping Zhong²  Sixian Lao²  Tao Zhou⁵  Weiwei Zeng⁵ 

[1] College of Medicine, Chang Gung University, Taoyuan, Taiwan;

[2] Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, China;

[3] Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China;

[4] Kawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;

[5] Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China;

[6] The Second People's Hospital of Longgang District, Shenzhen, China;

关键词: Kawasaki disease;    coronary artery lesions;    risk factors;    antibiotics;    children;   

DOI  :  10.3389/fpubh.2022.817613

来源: DOAJ

【 摘 要 】

ObjectivesTo study the impact of antibiotics used in Kawasaki disease (KD) with coronary artery lesions (CAL) and identify independent risk factors.MethodologyThis study reviewed the records of 287 KD patients between the years 2016 and 2020. Patients were grouped by their outcome, the CAL group, and a no-coronary artery lesions (NCAL) group, and stratified by the use of antibiotics. We collected clinical and laboratory data before the intravenous immunoglobulin (IVIG) treatment.ResultsThe two groups of KD patients with and without CAL were compared. The results showed that there are significant differences between groups which were erythrocyte count (p = 0.045) and hemoglobin (p = 0.005), red blood cell-specific volume (p = 0.001), immature granular cells percentage (p = 0.006), total protein (p = 0.045), albumin (p = 0.041), alkaline phosphatase (p = 0.023), and chlorine (p = 0.006). After multivariate logistic regression, neutrophil granulocyte percentage (odds ratio [OR] = 1.200, 95% confidence interval [CI]: 1.008-1.428, p = 0.040), lymphocyte percentage (p = 0.028, OR = 1.243, 95% CI: 1.024-1.508, p = 0.028) and total protein (OR = 4.414, 95% CI: 1.092-17.846, p = 0.037) were found to be independent risk factors for CAL. After analyzing the cases with a history of antibiotic use, multivariate analysis showed no indicators were considered independent risk factors for CAL.ConclusionNeutrophil granulocyte percentage, Lymphocyte percentage and total protein were independent risks for CAL in KD without antibiotics use history. The use of antibiotics affected physiological indicators of KD patients.

【 授权许可】

Unknown