Relationship Between Dry Eye Disease and Emotional Disorder: The Mediating Effect of Health Anxiety

Frontiers in Public Health

article

Qing He¹  Zhuo Chen¹  Caiyuan Xie¹  Lin Liu¹  Haibo Yang²  Ruihua Wei¹ 

[1] Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital;Academy of Psychology and Behavior, Tianjin Normal University, Tianjin Social Science Laboratory of Students' Mental Development and Learning

关键词: anxiety;    depression;    dry eye disease;    emotion;    health anxiety;   

DOI  :  10.3389/fpubh.2022.771554

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective This study aims to investigate the relationship between dry eye disease (DED) and anxiety, as well as DED and depression. Additionally, the influence of health anxiety (HA) on this relationship was determined. Methods A total of 206 patients with DED were recruited from Tianjin Medical University Eye Hospital clinic and surveyed using demographic questionnaires, the Ocular Surface Disease Index (OSDI), Hospital Anxiety and Depression Scale (HADS), and Short Health Anxiety Inventory (SHAI). Additionally, they were examined using Keratograph 5M and assessed for DED by corneal fluorescein staining. Regression analysis and the bootstrap method were used to investigate the influence of HA on the relationship between DED and emotional disorders. Results Among the 206 patients with DED, 52 (25.24%) and 56 (27.18%) patients showed depression and anxiety, respectively. The OSDI score and HA were positively correlated with depression and anxiety ( P < 0.01). The direct effects of OSDI on depression and anxiety were significant (95% confidence interval [CI]: 0.017–0.069; 0.008–0.060). Additionally, the bootstrap test showed significant mediating effects of HA (95% CI: 0.001–0.016; 0.003–0.021). The results suggested that the severity of DED symptoms, as measured by the OSDI score, affected anxiety and depression by a direct and an indirect pathway mediated by HA. Conclusions We found a significant correlation between DED and anxiety and depression. Moreover, HA was a mediator of the relationship between DED symptoms and anxiety and depression.

【 授权许可】

CC BY