Emotional Modulation of Episodic Memory and Translational Applications to Aging and Depression-Related Cognitive Impairment

memory;emotion;aging;depression;Neuroscience

Leal, Stephanie LaurenAlbert, Marilyn S. ;

Johns Hopkins University

关键词: memory;    emotion;    aging;    depression;    Neuroscience;   

Others  :  https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/40274/LEAL-DISSERTATION-2016.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: JOHNS HOPKINS DSpace Repository

【 摘 要 】

Important events in our lives, whether good or bad, ;;leave a scar upon the cerebral tissue”, as William James stated (James, 1890). While emotional experiences feel better remembered, not all aspects of an emotional experience are well retained. Trade-offs exist in remembering gist and detail information of emotional experiences, where gist information may be more beneficial to hold onto rather than focusing on minute details. A critical component of episodic memory is the ability to overcome interference from overlapping or similar experiences such that they can be stored independently. Understanding the dynamics of how significant memories are stored is crucial to uncovering how our memory system works, how this system may be altered in states of cognitive impairment, and how we might be able to target specific aspects of memory processing to either enhance or impair memory for certain experiences. Using a combination of sensitive cognitive measures, high-resolution functional imaging techniques, and translational applications of these approaches to populations with cognitive impairment (aging, depression, and late-life depression), we investigated amygdala-hippocampal dynamics during performance of an emotional mnemonic discrimination task that is thought to tax hippocampal pattern separation of emotional information. We found unique cognitive and neurobiological profiles in healthy adults as well as in states of aging, depression, and late-life depression.