Embryology of the Abdominal Wall and Associated Malformations—A Review

Frontiers in Surgery

article

Elisabeth Pechriggl¹  Michael Blumer¹  R. Shane Tubbs²  Łukasz Olewnik⁹  Marko Konschake¹  René Fortélny^1,10  Hannes Stofferin¹  Hanne Rose Honis¹  Sara Quinones^1,11  Eva Maranillo^1,11  José Sanudo^1,11 

[1] Institute of Clinical and Functional Anatomy, Medical University of Innsbruck;Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine;Department of Neurology, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine;Department of Anatomical Sciences, St. George’s University;Department of Structural & Cellular Biology, Tulane University School of Medicine;Department of Surgery, Tulane University School of Medicine;Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System;University of Queensland;Department of Anatomical Dissection and Donation, Medical University of Lodz;Department of General;Department of Anatomy and Embryology, School of Medicine, Complutense University of Madrid

关键词: embryology;    human;    abdominal wall;    congenital hernia;    developmental cascade;   

DOI  :  10.3389/fsurg.2022.891896

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

In humans, the incidence of congenital defects of the intraembryonic celom and its associated structures has increased over recent decades. Surgical treatment of abdominal and diaphragmatic malformations resulting in congenital hernia requires deep knowledge of ventral body closure and the separation of the primary body cavities during embryogenesis. The correct development of both structures requires the coordinated and fine-tuned synergy of different anlagen, including a set of molecules governing those processes. They have mainly been investigated in a range of vertebrate species (e.g., mouse, birds, and fish), but studies of embryogenesis in humans are rather rare because samples are seldom available. Therefore, we have to deal with a large body of conflicting data concerning the formation of the abdominal wall and the etiology of diaphragmatic defects. This review summarizes the current state of knowledge and focuses on the histological and molecular events leading to the establishment of the abdominal and thoracic cavities in several vertebrate species. In chronological order, we start with the onset of gastrulation, continue with the establishment of the three-dimensional body shape, and end with the partition of body cavities. We also discuss well-known human etiologies.

【 授权许可】

CC BY