Embryology of the Abdominal Wall and Associated Malformations—A Review

Frontiers in Surgery

卷:9

Hannes Stofferin²  José Sanudo³  Eva Maranillo³  Marko Konschake⁴  R. Shane Tubbs⁷  Sara Quinones¹¹  Michael Blumer¹¹  Hanne Rose Honis¹¹  Elisabeth Pechriggl¹¹  René Fortélny¹¹  Łukasz Olewnik¹² 

[1] Cellular Biology, Tulane University School of Medicine, New Orleans, LA, United States;

[2] 0Department of General, Visceral, and Oncological Surgery, Wilhelminenspital, Vienna, Austria;

[3] 1Department of Anatomy and Embryology, School of Medicine, Complutense University of Madrid, Madrid, Spain;

[4] Department of Anatomical Dissection and Donation, Medical University of Lodz, Lodz, Poland;

[5] Department of Anatomical Sciences, St. George’s University, St. George’s, Grenada, West Indies;

[6] Department of Neurology, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, United States;

[7] Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System, New Orleans, LA, United States;

[8] Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, United States;

[9] Department of Structural &

[10] Department of Surgery, Tulane University School of Medicine, New Orleans, LA, United States;

[11] Institute of Clinical and Functional Anatomy, Medical University of Innsbruck (MUI), Innsbruck, Austria;

[12] University of Queensland, Brisbane, Australia;

关键词: embryology;    human;    abdominal wall;    congenital hernia;    developmental cascade;   

DOI  :  10.3389/fsurg.2022.891896

来源: DOAJ

【 摘 要 】

In humans, the incidence of congenital defects of the intraembryonic celom and its associated structures has increased over recent decades. Surgical treatment of abdominal and diaphragmatic malformations resulting in congenital hernia requires deep knowledge of ventral body closure and the separation of the primary body cavities during embryogenesis. The correct development of both structures requires the coordinated and fine-tuned synergy of different anlagen, including a set of molecules governing those processes. They have mainly been investigated in a range of vertebrate species (e.g., mouse, birds, and fish), but studies of embryogenesis in humans are rather rare because samples are seldom available. Therefore, we have to deal with a large body of conflicting data concerning the formation of the abdominal wall and the etiology of diaphragmatic defects. This review summarizes the current state of knowledge and focuses on the histological and molecular events leading to the establishment of the abdominal and thoracic cavities in several vertebrate species. In chronological order, we start with the onset of gastrulation, continue with the establishment of the three-dimensional body shape, and end with the partition of body cavities. We also discuss well-known human etiologies.

【 授权许可】

Unknown