Involving Animal Models in Uterine Transplantation

Frontiers in Surgery

article

Angeline Favre-Inhofer¹  Marie Carbonnel¹  Johanna Domert³  Nathalie Cornet¹  Sylvie Chastant³  Raphaël Coscas⁴  François Vialard²  Valérie Gelin²  Laurent Galio²  Christophe Richard²  Héla Trabelsi²  Olivier Sandra²  Dominique de Ziegler¹  Pascale Chavatte-Palmer²  Jean-Marc Ayoubi¹ 

[1] Department of Gynaecology and Obstetrics, Foch Hospital;Université Paris-Saclay;NeoCare, ENVT, Université de Toulouse;Department of Vascular Surgery, Ambroise Paré University Hospital;UMR 1018, Inserm-Paris11 - CESP, Versailles Saint-Quentin-en-Yvelines University, Paris-Saclay University;École Nationale Vétérinaire d'Alfort;Département de Génétique, Laboratoire de Biologie Médicale

关键词: uterus;    transplantation;    surgery;    sheep;    animal;    animal models;   

DOI  :  10.3389/fsurg.2022.830826

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Absolute uterine factor infertility affects 0. 2% women of childbearing age around the world. Uterine transplantation (UTx) is a promising solution for many of them since the first birth from UTx was described by the Swedish team in 2014. The success of Utx in humans has become possible after a systematic and meticulous approach involving years of research on animal models. To date, more than 80 UTx procedures have been performed worldwide and 30 children were born. Material and Method This review summarizes the research preparation conducted in animals before beginning UTx in humans. It focuses on the advantages and limits of each animal model, their place in surgical training, and current contribution in research to improve UTx successes in humans. The different steps in the process of UTx have been analyzed, such as imaging, surgery, ischemia-reperfusion effects, rejection markers, immunosuppressive treatment, and pregnancy. Conclusion Animal models have played an essential role in the implementation of UTx, which is a highly complex procedure. While respecting the 3R requirements (replacement, refinement, and reduction), the surgical training using large animal models, such as notably ewes remain irreplaceable for teams wishing to initiate a UTx program. Furthermore, animal models are still mandatory in current research to improve the success rates of UTx in humans as well as to reduce the morbidity associated with this experimental infertility treatment.

【 授权许可】

CC BY