Uterus Transplantation with Live Donors: Screening Candidates in One French Center

Journal of Clinical Medicine

卷:9

MorganLe Guen¹  Renaud Snanoudj²  JeanMarc Ayoubi³  Marie Carbonnel³  Aurelie Revaux³  Lea Karpel³  Elena Menzhulina³  DominiqueDe Ziegler³ 

[1] Department of Anesthesiology, Hospital Foch, University of Versailles, Saint-Quentin-en-Yvelines, 55, avenue de Paris, 78000 Versailles, France;

[2] Department of Nephrology and Transplantation, University of Versailles, Saint-Quentin-en-Yvelines, 55, avenue de Paris, 78000 Versailles, France;

[3] Department of Obstetrics and Gynecology, Hospital Foch, University of Versailles, Saint-Quentin-en-Yvelines, 55, avenue de Paris, 78000 Versailles, France;

关键词: uterine;    uterus;    transplant;    transplantation;    screening;   

DOI  :  10.3390/jcm9062001

来源: DOAJ

【 摘 要 】

We report our experience regarding the profile and screening process of potential recipients (R) and their live donors (D) in our Uterus transplantation (UTx) trial from 2014 to 2020. The initial screening was performed using medical questionnaires and consultations. The second step of the screening consisted of two individual interviews with an independent multidisciplinary committee. Then, a complete medical, biological and imaging assessment of the directed living D, the R, and her partner was performed over a two-day hospitalization. A total of 239 women contacted our department: 165 potentials R and 74 potentials D. During the first step of screening, 141 R and 45 D were excluded. Only 12 R/D pairs were pursued. During inclusion, 10 R/D pairs were excluded. One R/D pair is still under evaluation. Finally, only 1 R/D pair was definitively included (0.6%), which led us to perform the first French UTx in March 2019 with a successful graft. The primary limiting factors of inclusion were due to very strict criteria and difficulty of having a suitable directed living D. The International Society of UTx (ISUTx) guidelines based on worldwide results of trials can help ease our inclusion criteria in the future while remaining safe for patients.

【 授权许可】

Unknown