Increased Il-8 Levels in the Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis

European Journal of Inflammation

Original Articles

V. Silani¹  M. Corbo²  C. Lunetta²  R. Mantegazza³  R. Tonelli⁴  E. Beghi⁴  M. Mengozzi⁴  P. Ghezzi⁴  L. Giordano⁴  T. Mennini⁴ 

[1] Dept. Neurology and “Dino Ferrari” Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milano;;Dept. Neurology and “Dino Ferrari” Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milano;;NEuroMuscular Omnicenter (NEMO), Fondazione Serena Onlus, Milano, Italy;Istituto Nazionale Neurologico Carlo Besta, Milano;;Istituto di Ricerche Farmacologiche Mario Negri, Milano;;

关键词: chemokines;    IL-8;    CXCR2;    amyotrophic lateral sclerosis;    cerebro spinal fluid;   

DOI  :  10.1177/1721727X0900700105

 received in 2008-10-17, accepted in 2009-03-09,  发布年份 2009

来源: Sage Journals

【 摘 要 】

Inflammation has been implicated in the pathogenesis of many neurodegenerative diseases. The chemokine IL-8 is thought to have a pathophysiological role in neurodegenerative diseases. IL-8 has recently been shown to induce death of primary cultured motor neurons in vitro. We determined IL-8 levels in the cerebrospinal fluid (CSF) from 38 patients with sporadic amyotrophic lateral sclerosis (ALS) compared to patients with other non-inflammatory neurological diseases (cerebrovascular disease, degenerative dementia, Parkinson's disease, compressive radiculo-myelopathy). Multiple sclerosis (MS) patients were used as positive controls. The levels of IL-8 in the CSF of ALS patients were significantly higher than those of patients with other, non-inflammatory neurological conditions and similar to those of MS patients. The only variable influencing IL-8 in ALS patients was sex, with higher levels in men than in women. The presence of the inflammatory cytokine IL-8 in the CSF of patients with ALS at the time of diagnosis strengthens the hypothesis of a role for this chemokine in neurodegenerative disorders.

【 授权许可】

Unknown   
© 2009 SAGE Publications Ltd