Intracranial Transplant of Olfactory Ensheathing Cells in Children and Adolescents with Cerebral Palsy: A Randomized Controlled Clinical Trial

Cell Transplantation

Brief Communication

Yushui Ren¹  Changman Zhou²  Qingmiao Wang³  Di Chen³  Ruiwen Liu³  Yancheng Liu³  Zihang Xie³  Zhao Jiang³  Feng Zhang³  Hongmei Wang⁴  Haitao Xi⁴  Hongyun Huang⁴  Lin Chen⁴ 

[1] Beijing Hongtianji Neuroscience Academy, Beijing, P.R. China;Beijing Hongtianji Neuroscience Academy, Beijing, P.R. China;Department of Anatomy and Embryology, Peking University Health Science Center, Beijing, P.R. China;Center for Neurorestoratology, Beijing Rehabilitation Center, Beijing, P.R. China;Center for Neurorestoratology, Beijing Rehabilitation Center, Beijing, P.R. China;Beijing Hongtianji Neuroscience Academy, Beijing, P.R. China;

关键词: Cerebral palsy;    Olfactory ensheathing cells;    Transplantation;    Clinical trial;    Key point for neural network restoration (KPNNR);   

DOI  :  10.3727/096368910X492652

来源: Sage Journals

【 摘 要 】

Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients. The patients were randomly assigned into two groups (treatment group, n = 18; control group, n = 15), and OECs derived from aborted fetal tissue were injected into the bilateral corona radiata in the frontal lobes (a key point for neural network restoration, KPNNR). The Gross Motor Function Measure (GMFM-66) and the Caregiver Questionnaire Scale were used to evaluate the patients' neurological function and overall health status. Among the 14 patients who completed the 6-month study, six received the cell transplantation and the other eight served as controls. In OEC treatment group, GMFM-66 scores were 26.67 ± 25.33 compared with 19.00 ± 20.00 for the control group. Concurrently, the Caregiver Questionnaire Scale score decreased to 77.83 ± 15.99 in the treatment group in comparison to 138.66 ± 64.06 of the control group. This trial, albeit small in sample size, indicates OEC KPNNR transplantation is effective for functional improvement in children and adolescents with CP, yet without obvious side effects. This small-scale study suggests that the procedure may be a plausible alternative method to treat this not yet curable disorder, and we urge further evaluation with a large-scale RCT.

【 授权许可】

Unknown   
© 2010 Cognizant Comm. Corp.

【 图 表 】

Figure 4.