期刊论文详细信息
Breast Cancer: Basic and Clinical Research
Exemestane in the Adjuvant Treatment of Breast Cancer in Postmenopausal Women
Expert Review
Muaiad Kittaneh1  Stefan Glück1 
[1] University of Miami, Leonard M. Miller School of Medicine, 1475 NW 12th Avenue, Suite 3310, Miami, Florida, USA;
关键词: aromatase inhibitor;    breast cancer;    exemestane;    disease-free survival;    tamoxifen;   
DOI  :  10.4137/BCBCR.S6234
来源: Sage Journals
PDF
【 摘 要 】

Exemestane is an irreversible inhibitor of the aromatase enzyme, which is a key component in the production of estrogen. The majority of breast cancers are sensitive to the proliferative effects of estrogen. Exemestane is approved for the adjuvant treatment of postmenopausal women with breast cancer after 2 to 3 years of tamoxifen therapy, based on a 32% improvement in disease-free survival compared with 5 years of tamoxifen alone (P < 0.001). Exemestane has also shown clinical benefits as an upfront therapy. The safety profile of exemestane shares some side effects with tamoxifen (hot flashes and arthralgia), but is not associated with an increased risk of endometrial cancer or thromboembolic events. This review will discuss in detail the efficacy and safety of exemestane in early breast cancer.

【 授权许可】

CC BY-NC   
© 2011 SAGE Publications.

【 预 览 】
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Table 3. 558KB Table download
Figure 2. 29KB Image download
Figure 6 29KB Image download
Figure 5. 773KB Image download
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Table 2. 99KB Table download
Figure 5. 58KB Image download
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