Upper-Extremity Deep Vein Thrombosis in Patients With Breast Cancer With Chest Versus Arm Central Venous Port Catheters

Breast Cancer: Basic and Clinical Research

Original Research

Danielle Tippit¹  Aneesha Ananthula¹  Daniella Ochoa²  Mark Rowe²  Erica Hill²  Amelia Merrill²  Ronda Henry-Tillman²  Issam Makhoul³  Angela Pennisi³  Eric Siegel⁴ 

[1] Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.;Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.;Division of Medical Oncology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.;Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.;

关键词: Upper extremity deep venous thrombosis;    breast cancer;    chemotherapy;    central venous port catheter;   

DOI  :  10.1177/1178223418771909

 received in 2017-09-30, accepted in 2018-03-29,  发布年份 2018

来源: Sage Journals

【 摘 要 】

Most of the patients undergoing treatment for cancer require placement of a totally implantable venous access device to facilitate safe delivery of chemotherapy. However, implantable ports also increase the risk of deep vein thrombosis and related complications in this high-risk population. The objective of this study was to assess the incidence of upper-extremity deep vein thrombosis (UEDVT) in patients with breast cancer to determine whether the risk of UEDVT was higher with chest versus arm ports, as well as to determine the importance of previously reported risk factors predisposing to UEDVT in the setting of active cancer. We retrospectively reviewed the medical records of 297 women with breast cancer who had ports placed in our institution between the dates of December 1, 2010, and December 31, 2016. The primary outcome was the development of radiologically confirmed UEDVT ipsilateral to the implanted port. Overall, 17 of 297 study subjects (5.7%) were found to have UEDVT. There was 1 documented case of associated pulmonary embolism. Fourteen (9.5%) of 147 subjects with arm ports experienced UEDVT compared with only 3 (2.0%) of 150 subjects with chest ports (P = .0056). Thus, implantation of arm ports as opposed to chest ports may be associated with a higher rate of UEDVT in patients with breast cancer.

【 授权许可】

CC BY-NC   
© The Author(s) 2018

【 图 表 】

Photo 8.