In Vivo Tracking of Human Mesenchymal Stem Cells in Experimental Stroke

Cell Transplantation

Article

Tae-Sun Hwang¹  Byoung-Gi Chun¹  Iksoo Jeon¹  Jihwan Song¹  Yong Hyun Lee²  Hyungmin Chung²  Yeon-Kyung Kim²  Byoung Joo Gwag³  Chaejoon Cheong⁴  Kwan Soo Hong⁴  Cheong-Soo Park⁴  Daehong Kim⁴ 

[1] CHA Stem Cell Institute, Pochon CHA University College of Medicine, Seoul, Korea;CHA Stem Cell Institute, Pochon CHA University College of Medicine, Seoul, Korea;Stem Cell Therapy Institute, CHA Biotech Co., Ltd., Seoul, Korea;Department of Pharmacology, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea;MRI Team, Korea Basic Science Institute, Ochang, Korea;

关键词: Migration;    Human mesenchymal stem cells (hMSCs);    Middle cerebral artery occlusion (MCAo);    Magnetic resonance imaging (MRI);   

DOI  :  10.3727/000000007783472381

 received in 2007-02-02, accepted in 2007-07-16,  发布年份 2007

来源: Sage Journals

【 摘 要 】

To understand the fates of human mesenchymal stem cells (hMSCs) following transplantation into a rodent model of middle cerebral artery occlusion (MCAo), magnetic resonance imaging (MRI) techniques were employed. hMSCs were labeled with ferumoxides (Feridex®)-protamine sulfate complexes, which were visualized and examined by MRI up to 10 weeks following transplantation. Migration of the transplanted cells to the infarcted area was further confirmed by histological methods. We found that the hMSCs transplanted in MCAo models possess the capacity to migrate to the infarcted area extensively in both ipsilateral and contralateral injections, exhibiting a pathotropism. We also analyzed the detailed migration patterns of transplanted hMSCs. We speculate that the extensive migratory ability of hMSCs may represent a therapeutic potential for developing efficient cell transplantation strategies in stroke.

【 授权许可】

Unknown   
© 2007 Cognizant Comm. Corp.