期刊论文详细信息
Cell Transplantation
In Vivo Tracking of Human Mesenchymal Stem Cells in Experimental Stroke
Article
Tae-Sun Hwang1  Byoung-Gi Chun1  Iksoo Jeon1  Jihwan Song1  Yong Hyun Lee2  Hyungmin Chung2  Yeon-Kyung Kim2  Byoung Joo Gwag3  Chaejoon Cheong4  Kwan Soo Hong4  Cheong-Soo Park4  Daehong Kim4 
[1] CHA Stem Cell Institute, Pochon CHA University College of Medicine, Seoul, Korea;CHA Stem Cell Institute, Pochon CHA University College of Medicine, Seoul, Korea;Stem Cell Therapy Institute, CHA Biotech Co., Ltd., Seoul, Korea;Department of Pharmacology, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea;MRI Team, Korea Basic Science Institute, Ochang, Korea;
关键词: Migration;    Human mesenchymal stem cells (hMSCs);    Middle cerebral artery occlusion (MCAo);    Magnetic resonance imaging (MRI);   
DOI  :  10.3727/000000007783472381
 received in 2007-02-02, accepted in 2007-07-16,  发布年份 2007
来源: Sage Journals
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【 摘 要 】

To understand the fates of human mesenchymal stem cells (hMSCs) following transplantation into a rodent model of middle cerebral artery occlusion (MCAo), magnetic resonance imaging (MRI) techniques were employed. hMSCs were labeled with ferumoxides (Feridex®)-protamine sulfate complexes, which were visualized and examined by MRI up to 10 weeks following transplantation. Migration of the transplanted cells to the infarcted area was further confirmed by histological methods. We found that the hMSCs transplanted in MCAo models possess the capacity to migrate to the infarcted area extensively in both ipsilateral and contralateral injections, exhibiting a pathotropism. We also analyzed the detailed migration patterns of transplanted hMSCs. We speculate that the extensive migratory ability of hMSCs may represent a therapeutic potential for developing efficient cell transplantation strategies in stroke.

【 授权许可】

Unknown   
© 2007 Cognizant Comm. Corp.

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【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
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