The Potential Roles of EZH2 in Regenerative Medicine

Cell Transplantation

Review

Woei-Cherng Shyu¹  Lian Chiu²  Ruey-Hwang Chou³  Yung-Luen Yu³ 

[1] Center for Neuropsychiatry and Translational Medicine Research Center, China Medical University and Hospital, Taichung, Taiwan; Graduate Institute of Immunology, China Medical University, Taichung, Taiwan;Department of Nursing, College of Medicine and Nursing, Hungkuang University, Taichung, Taiwan;Graduate Institute of Cancer Biology, Center for Molecular Medicine, China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Taichung, Taiwan;

关键词: Enhancer of zeste homolog 2 (EZH2);    Stem cells;    Cell lineage;    Differentiation;    Regenerative medicine;   

DOI  :  10.3727/096368915X686823

 received in 2014-12-09, accepted in 2015-01-27,  发布年份 2015

来源: Sage Journals

【 摘 要 】

Enhancer of zeste homolog 2 (EZH2), a catalytic component of polycomb repressive complex 2, serves as a histone methyltransferase toward histone H3K27 trimethylation and also recruits DNA methyltransferases to regulate gene expression and chromatin structure. Accumulating evidence indicates the critical roles of EZH2 in stem cell maintenance and cell fate decision in differentiation into specific cell lineages. In this article, we review the updated progress in the field and the potential application of EZH2 in regenerative medicine including nervous system, muscle, pancreas, and dental pulp regeneration.

【 授权许可】

Unknown   
© 2015 Cognizant Comm. Corp.

【 图 表 】

Figure 1