Direct Reprogrammed Neuronal Cells as a Novel Resource for Cell Transplantation Therapy

Cell Transplantation

Review

Koji Abe¹  Toru Yamashita¹ 

[1]Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

关键词: Induced pluripotent stem cells (iPSCs);    Induced neuronal cells (iNCs);    Induced neural stem cells (iNSCs);    Direct conversion;    Cell transplantation;   

DOI  :  10.3727/096368914X678274

 received in 2013-10-30, accepted in 2014-02-05,  发布年份 2014

来源: Sage Journals

【 摘 要 】

Cell transplantation/replacement therapy is attractive as a novel strategy for neurological diseases such as Parkinson's disease, Alzheimer's disease, and stroke. To realize this therapy, safer and more therapeutic effective cell resources are now required. Since induced pluripotent stem cells (iPSCs) can retain high replication competence and pluripotency when they differentiate into various kinds of cells, they are regarded as a promising cell source for cell transplantation therapy. However, high tumorigenesis of iPSCs has to be overcome for clinical applications. Recent progress includes the combination of novel transcriptional factors that can convert somatic cells to various kinds of mature neuronal cells and neural stem cells without requiring iPSC fate. Some evidence indicates that these directly induced neuronal cells have little tumorigenic potential. In this article, we discuss the advantage, issues, and possibility of clinical application of these cells for cell transplantation therapy.

【 授权许可】

Unknown   
© 2014 Cognizant Comm. Corp.

【 图 表 】

Figure 11.

Figure 1.