The Fetal Dermal but Not Loose Fascial Mesenchymal Cells Possess Regenerative Activity of Dermal Structure

Cell Transplantation

Article

Nobuaki Imanishi¹  Hideo Nakajima²  Tatsuo Nakajima²  Kazuo Kishi²  Hiroko Satoh³  Kenichi Katsube⁴ 

[1] Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi Shinjukuku, Tokyo, 160–8582 Japan;Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjukuku, Tokyo, 160–8582 Japan;Department of Plastic and Reconstructive Surgery, National Tokyo Medical Center, Tokyo, 152–8902 Japan;Molecular Pathology, Graduate School of Tokyo Medical and Dental University, Tokyo, 113–8549 Japan;

关键词: Fetal wound healing;    Regeneration;    scid mouse;    Dermal;   

DOI  :  10.3727/000000005783982729

来源: Sage Journals

【 摘 要 】

Fetal skin possesses a regenerative activity until certain developmental stages. However, the origin of cells that regenerate dermis after wounding has not been clarified yet. In the present study we located the origin of cells that reconstruct fetal dermal structure by histological examination and by marking cells in the loose fascia. Next we evaluated the regenerative activity of fetal dermal mesenchymal cells by cotransplanting with fetal epidermal cells onto the skin defect of scid mice. We conclude that fetal dermal mesenchymal cells but not loose fascial cells possess regenerative activity even on the environment in scid mice.

【 授权许可】

Unknown   
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