Amnion: A Potent Graft Source for Cell Therapy in Stroke

Cell Transplantation

Review

Maddalena Soncini¹  Ornella Parolini¹  David C. Hess²  Seong Jin Yu²  Yuji Kaneko²  Cesar V. Borlongan³ 

[1] Centro di Ricerca E. Menni, Fondazione Poliambulanza Instituto Ospedaliero, Brescia, Italy;Department of Neurology, Medical College of Georgia, Augusta, GA, USA;Department of Neurology, Medical College of Georgia, Augusta, GA, USA;Institute of Molecular Medicine Genetics, Medical College of Georgia, Augusta, GA, USA;

关键词: Adult stem cells;    Progenitors;    Placenta;    Mesenchymal stromal cells;    Transplantation;    Cerebral ischemia;   

DOI  :  10.3727/096368909788341243

 received in 2008-06-25, accepted in 2008-09-12,  发布年份 2009

来源: Sage Journals

【 摘 要 】

Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attracted attention as a novel cell source for cell transplantation therapy. Cells isolated from amniotic membrane can differentiate into all three germ layers, have low immunogenicity and anti-inflammatory function, and do not require the destruction of human embryos for their isolation, thus circumventing the ethical debate commonly associated with the use of human embryonic stem cells. Accumulating evidence now suggests that the amnion, which had been discarded after parturition, is a highly potent transplant material in the field of regenerative medicine. In this report, we review the current progress on the characterization of MSCs derived from the amnion as a remarkable transplantable cell population with therapeutic potential for multiple CNS disorders, especially stroke.

【 授权许可】

Unknown   
© 2009 Cognizant Comm. Corp.

【 图 表 】

Figure 8.

Figure 4.