Evidence-Based Pharmacotherapy for Pediatric Obsessive-Compulsive Disorder and Chronic Tic Disorders

Journal of Central Nervous System Disease

Review

Adam B. Lewin¹  Tanya K. Murphy¹  Alessandro S. De Nadai²  Joseph F. Mcguire²  Eric A. Storch³ 

[1] Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA.; Department of Psychiatry and Behavioral Sciences, University of South Florida College of Medicine, Tampa, FL, USA.;Department of Psychology, University of South Florida, Tampa, FL, USA.;Department of Psychology, University of South Florida, Tampa, FL, USA.; Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA.; Department of Psychiatry and Behavioral Sciences, University of South Florida College of Medicine, Tampa, FL, USA.;

关键词: obsessive-compulsive disorder;    tic disorders;    Tourette disorder;    psychopharmacology;   

DOI  :  10.4137/JCNSD.S6616

来源: Sage Journals

【 摘 要 】

In recent years, much progress has been made in pharmacotherapy for pediatric obsessive-compulsive disorder (OCD) and chronic tic disorders (CTDs). What were previously considered relatively intractable conditions now have an array of efficacious medicinal (and psychosocial) interventions available at clinicians' disposal, including selective serotonin reuptake inhibitors, atypical antipsychotics, and alpha-2 agonists. The purpose of this review is to discuss the evidence base for pharmacotherapy with pediatric OCD and CTDs with regard to efficacy, tolerability, and safety, and to put this evidence in the context of clinical management in integrated behavioral healthcare. While there is no single panacea for these disorders, there are a variety of medications that provide considerable relief for children with these disabling conditions.

【 授权许可】

CC BY-NC   
© 2011 SAGE Publications.

【 图 表 】

Figure 2.