Virulence Factors of Helicobacter pylori: A Review

Clinical Medicine Insights: Gastroenterology

Article

Bruna M. Roesler¹  José M.R. Zeitune¹  Elizabeth M.A. Rabelo-Gonçalves¹ 

[1] Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil.;Center of Diagnosis of Digestive Diseases, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil.;

关键词: Helicobacter pylori;    virulence factors;    chronic gastritis;    peptic ulcer disease;    gastric adenocarcinoma;   

DOI  :  10.4137/CGast.S13760

 received in 2013-12-01, accepted in 2014-02-17,  发布年份 2014

来源: Sage Journals

【 摘 要 】

Helicobacter pylori is a spiral-shaped Gram-negative bacterium that colonizes the human stomach and can establish a long-term infection of the gastric mucosa, a condition that affects the relative risk of developing various clinical disorders of the upper gastrointestinal tract, such as chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. H. pylori presents a high-level of genetic diversity, which can be an important factor in its adaptation to the host stomach and also for the clinical outcome of infection. There are important H. pylori virulence factors that, along with host characteristics and the external environment, have been associated with the different occurrences of diseases. This review is aimed to analyzing and summarizing the main of them and possible associations with the clinical outcome.

【 授权许可】

CC BY-NC   
© 2014 SAGE Publications.