Nitric Oxide and S-Nitrosylation in Cancers: Emphasis on Breast Cancer

Breast Cancer: Basic and Clinical Research

Review

Deepshikha Mishra¹  Vaibhav Patel²  Debabrata Banerjee² 

[1] Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA;Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA;School of Graduate Studies, Rutgers, The State University of New Jersey, Piscataway, NJ, USA;

关键词: Breast cancer;    nitric oxide;    nitric oxide synthase;    S-nitrosylation;    reactive nitrogen species;    redox switch;    nitrosative stress;   

DOI  :  10.1177/1178223419882688

 received in 2019-08-16, accepted in 2019-09-16,  发布年份 2020

来源: Sage Journals

【 摘 要 】

Nitric oxide (NO) is a ubiquitous, endogenously produced, water-soluble signaling molecule playing critical roles in physiological processes. Nitric oxide plays pleiotropic roles in cancer and, depending on its local concentration, may lead to either tumor progression or tumor suppression. Addition of NO group to a cysteine residue within a protein, termed as S-nitrosylation, plays diverse regulatory roles and affects processes such as metabolism, apoptosis, protein phosphorylation, and regulation of transcription factors. The process of S-nitrosylation has been associated with development of different cancers, including breast cancer. The present review discusses different mechanisms through which NO acts, with special emphasis on breast cancers, and provides detailed insights into reactive nitrogen species, posttranslational modifications of proteins mediated by NO, dual nature of NO in cancers, and the implications of S-nitrosylation in cancers. Our review will generate interest in exploring molecular regulation by NO in different cancers and will have significant therapeutic implications in the management and treatment of breast cancer.

【 授权许可】

CC BY-NC   
© The Author(s) 2020

【 图 表 】

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