Side Effects of the Immune System: Lessons from Tuberculosis-Related Immune Reconstitution Inflammatory Syndrome

European Journal of Inflammation

Editorial

O. Genovese¹  T. Pirronti²  L. Gargiullo³  D. Buonsenso³  O. Ranno³  P. Valentini³ 

[1] Department of Anesthesiology and Intensive Care, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy;Department of Bioimaging and Radiological Sciences, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy;Department of Pediatrics, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy;

关键词: IRIS;    TB;    HIV;    immune system;   

DOI  :  10.1177/1721727X1201000101

 received in 2011-08-11, accepted in 2012-01-20,  发布年份 2012

来源: Sage Journals

【 摘 要 】

Immune reconstitution inflammatory syndrome (IRIS) is a recently described syndrome among human immunodeficiency virus (HIV)-infected patients attributable to the recovery of the immune system during antiretroviral therapy. A growing number of researches on this syndrome have been conducted in recent years, but IRIS in children has not been widely studied. We report the case of a 4.5 month-old, tuberculosis (TB)-HIV co-infected girl who developed IRIS two months after beginning antiretroviral and anti-TB medications. We moreover review the immunopathogenesis of TB-HIV coinfection and IRIS, with particular regard to TB-related IRIS.

【 授权许可】

Unknown   
© 2012 SAGE Publications