Rational design of transcranial alternating current stimulation

Clinical and Translational Neuroscience

Article

Rebekka Kurmann¹  Kaspar Schindler¹  Heidemarie Gast¹  Flavio Fröhlich² 

[1] Sleep-Wake-Epilepsy-Center, Department of Neurology, InselSpital, University of Bern, Bern, Switzerland;Sleep-Wake-Epilepsy-Center, Department of Neurology, InselSpital, University of Bern, Bern, Switzerland;Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;

关键词: Network oscillations;    noninvasive brain stimulation;    tACS;    CNS disorders;    target identification;    target engagement;    target validation;    treatment;   

DOI  :  10.1177/2514183X18793515

来源: Sage Journals

【 摘 要 】

Network oscillations in the brain are routinely recorded in the clinic and in the research lab. Here we outline a new paradigm in which network oscillations serve as treatment targets for noninvasive brain stimulation. We show how transcranial alternating current stimulation (tACS) can be used to modulate network oscillations that are impaired in disorders of the central nervous system (CNS). Using rational design, a structured process of target identification, target engagement, and target validation can be deployed to develop effective noninvasive brain stimulation paradigms for the treatment of neurological and psychiatric illnesses. We conclude by outlining how this approach could be applied to two disorders of the CNS, depression and epilepsy, for which there already exist clinical brain stimulation treatment options.

【 授权许可】

CC BY-NC   
© The Author(s) 2018

【 图 表 】

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