Effect of Fusidic Acid on Pancreatic Islet Allograft Rejection

Cell Transplantation

Original Contribution

Enric Esmatjes¹  Alex Saenz¹  Laureano Fernandez-Cruz¹  Josá F. Mendola¹  Ramon Gomis¹  Helena Corominola¹ 

[1] Endocrinology and Nutrition Unit, Department of Surgery, Hospital Clínic of Barcelona, Villarroel 170, 08036 Barcelona, Spain;

关键词: Pancreatic islets;    Allograft;    Cyclosporin-A;    Fusidic acid;    Rejection;   

DOI  :  10.1177/096368979700600108

来源: Sage Journals

【 摘 要 】

We examined in fully mismatched rats, the survival of pancreatic islet allografts in recipients treated with either fusidic acid (FA), an antistaphyllococcal antibiotic that has been shown to possess an immunosuppressive effect in vitro and in vivo, or cyclosporin-A (CsA). Islets were isolated by collagenase digestion, separated from acinar tissue by handpicking under a dissecting microscope and transplanted into the liver by portal vein injection of streptozotocin(STZ)-induced diabetic rats. The results indicated that while a temporary immunosuppression with CsA achieved an indefinite islet allograft survival, FA administered to recipients daily was not able to prevent islet allograft rejection across a major histocompatibility barrier. We conclude that despite the fact that fusidic acid has been claimed to act as an immunosuppressant drug in vitro with effects similar to those of CsA, unlike CsA, FA given either orally or by s.c. injection was not effective to prolong islet allograft survival in vivo. Copyright © 1997 Elsevier Science Inc.

【 授权许可】

Unknown   
© 1997 Elsevier Science Inc.