Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

Molecules

关键词: laetispicine derivatives;    antidepressant;    total synthesis;    forced swimming test;   

DOI  :  10.3390/molecules17021425

来源: DOAJ

【 摘 要 】

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.

【 授权许可】

Unknown