Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

Molecules

Shuyi Yao¹  Hui Xie¹  Li Zhang¹  Tao Meng¹  Yongliang Zhang¹  Xin Wang¹  Lin Chen¹  Shengli Pan¹ 

[1] ¹State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China ²School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

关键词: laetispicine derivatives;    antidepressant;    total synthesis;    forced swimming test;   

DOI  :  10.3390/molecules17021425

来源: mdpi

【 摘 要 】

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.