Decreased Glucose Utilization Contributes to Memory Impairment in Patients with Glufosinate Ammonium Intoxication

Journal of Clinical Medicine

Samel Park¹  Hyo-Wook Gil¹  Nam-jun Cho¹  Jongkyu Park²  IkDong Yoo³  SangMi Lee³  SeWon Oh⁴  JoongIl Kim⁵ 

[1] Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea;Department of Neurology, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea;Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea;Department of Radiology, Eunpyung St. Mary’s Hospital, The Catholic University of Korea, Seoul 03312, Korea;Future Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea;

关键词: herbicides;    poisoning;    memory disorder;    positron emission tomography;    glufosinate ammonium;    F-18 flurodeoxyglucose;   

DOI  :  10.3390/jcm9041213

来源: DOAJ

【 摘 要 】

The symptoms of glufosinate ammonium (GLA) intoxication include gastrointestinal and neurologic symptoms, respiratory failure, and cardiovascular instability. Among these, neurologic symptoms including loss of consciousness, memory impairment, and seizure are characteristic of GLA poisoning. However, the mechanism of brain injury by GLA poisoning is still poorly understood. We investigated nine patients who had performed an F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scan because of memory impairment caused by GLA ingestion. FDG-PET images of patients with GLA intoxication were compared with 24 age- and sex-matched healthy controls to evaluate whether the patients had abnormal patterns of glucose metabolism in the brain. Decreased glucose metabolism was observed in the inferior frontal and temporal lobes of these patients with GLA intoxication when compared with 24 age- and sex-matched healthy controls. Three patients performed follow-up FDG-PET scans. However, it was shown that the results of the follow-up FDG-PET scans were determined to be inconclusive. Our study showed that memory impairment induced by GLA intoxication was associated with glucose hypometabolism in the inferior frontal and temporal lobes in the brain.

【 授权许可】

Unknown