Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency

Cell Regeneration

Suresh Ramakrishna¹  Kye-Seong Kim¹  Seok-Ho Hong²  Won Sun Park³  Himanshu Chauhan⁴  Young Jin Lee⁵ 

[1] Department of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea;Department of Internal Medicine, School of Medicine, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do 24341, South Korea;Department of Physiology, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea;Uppsala University, Uppsala 75236, Sweden;iDream Research Center, MizMedi Women's Hospital, Seoul 07639, South Korea;

关键词: miRNAs;    Embryonic stem cells;    Pluripotency;    Reprogramming;    Self-renewal;   

DOI  :  10.1186/s13619-016-0028-0

来源: DOAJ

【 摘 要 】

Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19–24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Embryonic stem cells (ESCs) represent a valuable tool for disease modeling, drug discovery, developmental studies, and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and pluripotency. Therefore, remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of pluripotency. Here, we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming, as well as the potential role of miRNAs in two distinct pluripotent states (naïve and primed).

【 授权许可】

Unknown