Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

Alzheimer’s Research & Therapy

Michael T. Heneka¹  Robert Brown²  Douglas Golenbock³  Eicke Latz³  Dave Morgan⁴ 

[1] Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn;Department of Neurology, University of Massachusetts Medical School;German Center for Neurodegenerative Disease;Translational Neuroscience, College of Human Medicine, Michigan State University;

关键词: Systemic inflammation;    NLRP3 inflammasome;    Cytokine;    Cognition;    Neurodegeneration;    Neuroinflammation;   

DOI  :  10.1186/s13195-020-00640-3

来源: DOAJ

【 摘 要 】

Abstract Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in a substantial proportion of affected patients. While these symptoms arise acutely during the course of infection, less is known about the possible long-term consequences for the brain. Severely affected COVID-19 cases experience high levels of proinflammatory cytokines and acute respiratory dysfunction and often require assisted ventilation. All these factors have been suggested to cause cognitive decline. Pathogenetically, this may result from direct negative effects of the immune reaction, acceleration or aggravation of pre-existing cognitive deficits, or de novo induction of a neurodegenerative disease. This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic.

【 授权许可】

Unknown