Recent Advances in αβ T Cell Biology: Wnt Signaling, Notch Signaling, Hedgehog Signaling and Their Translational Perspective

AIMS Medical Science

Kai Dai¹  Luokun Xie²  Wenping Lin³ 

[1] ;Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China;Department of Orthopedic Surgery, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, China;

关键词: αβ T cells;    Cell signaling;    Wnt;    Notch;    Hedgehog;   

DOI  :  10.3934/medsci.2016.4.312

来源: DOAJ

【 摘 要 】

Engagement of bioactive ligands with cell surface receptors plays critical roles in the initiation and regulation of αβ T cell development, homeostasis and functions. In the past two decades, new subpopulations of αβ T cells have been discovered. In addition, the characterization of new ligand/receptor axes has led to a better understanding of αβ T cell biology. In the current review, the phenotypic and functional properties of αβ T cell subpopulations are described, as well asthe effects of three novel and well-documented signal pathways—Wnt, Notch and Hedgehog signaling—on αβ T cell development and functions are summarized. These signal pathways are initiated by the ligation of corresponding ligands with respective receptors, and this subsequently exerts a positive or negative influence on αβ T cell ontogenesis and behavior. Thorough understanding of the components of these signal pathways might shed new light on the manipulation of αβ T cell biology so as to favor the advance of diagnosis and therapy of immune disorders such as infection, tumors and autoimmune diseases.

【 授权许可】

Unknown