Recent Advances in αβ T Cell Biology: Wnt Signaling, Notch Signaling, Hedgehog Signaling and Their Translational Perspective

AIMS Medical Science

article

Wenping Lin¹  Kai Dai²  Luokun Xie¹ 

[1] Department of Orthopedic Surgery, the Second Affiliated Hospital, Fujian Medical University;Department of Infectious Diseases, Renmin Hospital of Wuhan University;University of North Texas Health Science Center

关键词: αβ T cells;    Cell signaling;    Wnt;    Notch;    Hedgehog;    ;   

DOI  :  10.3934/medsci.2016.4.312

来源: American Institute of Mathematical Sciences

【 摘 要 】

Engagement of bioactive ligands with cell surface receptors plays critical roles in the initiation and regulation of αβ T cell development, homeostasis and functions. In the past two decades, new subpopulations of αβ T cells have been discovered. In addition, the characterization of new ligand/receptor axes has led to a better understanding of αβ T cell biology. In the current review, the phenotypic and functional properties of αβ T cell subpopulations are described, as well as the effects of three novel and well-documented signal pathways—Wnt, Notch and Hedgehog signaling—on αβ T cell development and functions are summarized. These signal pathways are initiated by the ligation of corresponding ligands with respective receptors, and this subsequently exerts a positive or negative influence on αβ T cell ontogenesis and behavior. Thorough understanding of the components of these signal pathways might shed new light on the manipulation of αβ T cell biology so as to favor the advance of diagnosis and therapy of immune disorders such as infection, tumors and autoimmune diseasesEngagement of bioactive ligands with cell surface receptors plays critical roles in the initiation and regulation of αβ T cell development, homeostasis and functions. In the past two decades, new subpopulations of αβ T cells have been discovered. In addition, the characterization of new ligand/receptor axes has led to a better understanding of αβ T cell biology. In the current review, the phenotypic and functional properties of αβ T cell subpopulations are described, as well as the effects of three novel and well-documented signal pathways—Wnt, Notch and Hedgehog signaling—on αβ T cell development and functions are summarized. These signal pathways are initiated by the ligation of corresponding ligands with respective receptors, and this subsequently exerts a positive or negative influence on αβ T cell ontogenesis and behavior. Thorough understanding of the components of these signal pathways might shed new light on the manipulation of αβ T cell biology so as to favor the advance of diagnosis and therapy of immune disorders such as infection, tumors and autoimmune diseases.

【 授权许可】

CC BY